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What is HGH (Human Growth Hormone)?

Human growth hormone (HGH) is one of the hormones of the hypothalamus, which is produced by the anterior pituitary gland. This hormone is often called somatotropin. HGH or somatotropin causes a pronounced acceleration of linear growth mainly due to the growth of long tubular bones (bones of the extremities). The usual concentration of growth hormone is 1-5 ng/mL. As for the peaks, it can reach the level of 10-20 ng/mL, and even 45 ng/mL.

HGH was thoroughly studied in 1956. It was shown that the growth hormone was secreted in the pituitary gland in response to the signals of the hypothalamus. HGH does not have sex differences. That is, the level of somatotropin is nearly the same for men and women.

HGH plays an important role in metabolism: it helps increase body mass index and reduce the amount of fat in the body. Human growth hormone stimulates liver cells to produce polypeptide molecules known as somatomedins. These agents affect all body systems. Some of their functions are listed below:

  • Muscular development;
  • Stimulation of linear growth;
  • Improvement of the skeletal structure;
  • Regulation of various functions related to metabolism;
  • Stimulation of normal brain function;
  • Improvement of cardiac function.

The secretion of human growth hormone decreases with age. It is established that the level of production of HGH by the pituitary gland decreases by 50% every 7 years (in people from 25 years and over). This may lead to a number of undesirable symptoms, which are usually associated with aging processes: fat accumulation, loss of muscle mass, disorders associated with cognitive functions (memory, speech), strength loss, lack of stamina, bone fragility, etc.

HGH effects:

  • Anabolic effect – HGH causes muscle growth.
  • HGH reduces fat accumulation.
  • Human growth hormone has a rejuvenating effect.
  • This agent stimulates the growth of internal organs (in case of age-related atrophy).
  • It causes bone growth, strengthens the bones and increases growth in young people up to 26 years of age.
  • HGH increases blood glucose levels.
  • It helps strengthen immunity.

Some effects of HGH are associated with the insulin-like growth factor (IGF-1, formerly called somatomedin C), which is produced in the liver. IGF-1 stimulates the growth of internal organs. Virtually all the effects of growth hormone are associated with the effects of IGF-1.

Hormone growth secretion: features

Just like with many other hormones, somatotropin secretion has several peaks during the day (as a rule, the secretion peak occurs every 3-5 hours). There are several peaks, during which the concentration of HGH increases significantly. The highest peak is observed at night (about an hour after falling asleep).
In addition, the secretion of human growth hormone is steadily decreasing because of age-related changes. The normal level of somatotropin is maximal in early childhood. The maximal secretion rates are higher in adolescents (during the period of intensive linear growth and puberty). When you are 25, the rates of synthesis of somatotropin gradually decrease.
Low synthesis of somatotropin with age is a normal physiological process. The main reason for concern is when the concentration of growth hormone goes beyond the limits of age norms – this is a pathological condition.
As a rule, the main causes of low synthesis of somatotropin in children include various congenital conditions. As for acquired disorders, these include hypoxia, head trauma, CNS tumors, etc. The main problems with growth hormone in adults occur in case of pituitary adenoma, as well as due to radiation exposure and brain surgery.
Hyperproduction of somatotropin leads to gigantism in children and acromegaly in adults. Insufficient levels of the growth hormone in children may cause dwarfism (with varying degrees of severity).

Somatotropin deficiency in adults has the following symptoms:

  • Obesity (fat accumulation mainly in the abdomen);
  • Early atherosclerosis;
  • Low level of physical activity;
  • Disorders of sexual function;
  • Osteoporosis.

In addition, it has been proved that low levels of somatotropin increase the risk of death from cardiovascular diseases.

Regulation of human growth hormone secretion

The main agents that regulate the production of HGH are peptidic substances produced by the hypothalamus (GHRH and GHIH). The balance of these substances is largely influenced by various physiological factors.
Factors that stimulate the production of growth hormone (increase the synthesis of GHRH by the hypothalamus):

  • Sleep;
  • Physical exercises;
  • Increased estrogen concentration;
  • Low blood sugar levels;
  • Hyperthyroidism;
  • Certain amino acids (lysine, arginine, ornithine, glutamine);
  • Ghrelin secretion (“hunger hormone”).

Factors that suppress the secretion of growth hormone (that is, stimulate the secretion of GHIH):

  • High blood sugar levels;
  • Hyperlipidemia;
  • High levels of growth hormone in the body (for example, too much artificial hormone).

How does HGH work?

Somatotropin (hgh) is a protein that contains 191 amino acids. Hgh production is a lifelong process. The usual level of somatotropin reaches its maximum in early childhood and adolescence. After that, the secretion is slightly reduced.

Somatotropin regulates the metabolism of bone tissue. This substance regulates the production of collagen in the tissues and organs, stimulates the processes of recovery, and reduces destructive processes. Moreover, it helps maintain strong bones, strengthen immune system, lower cholesterol and increase sexual activity.

Low hgh secretion leads to premature aging. One of the key effects of growth hormone is the greatest ability to rejuvenate your body and reduce the processes and visible signs of aging. As for women, some of the typical and unpleasant external signs of hgh deficiency include:

  • Wrinkles on the face and sagging, sunken cheeks;
  • Decreased muscle tone;
  • Excess weight gain.

Fortunately, these shortcomings can be corrected with the help of hgh injections. This will lead to general rejuvenation of your body. Somatropin will help improve your immunity and increase vitality. The effects are similar in both men and women.

Who can use HGH Injections?

You need to know how to properly prepare and use growth hormone to achieve a positive effect.

Injections of growth hormone are prescribed to both men and women older than 20 years of age. It is not desirable to use this drug in younger patients, since there is a risk of asymmetric bone growth and other negative consequences. The synthetic version of hgh is used in bodybuilding to boost muscle growth and reduce fat layer thickness.

Patients on hgh therapy need to adjust the amount of insulin and monitor their blood sugar levels daily. In most cases, it becomes necessary to slightly increase the dose of insulin.

Also, hgh injection should be used with caution in people with hypertension (due to the risk of high blood pressure). In any case, a doctor’s consultation is desirable to exclude the negative impact on the human body.

HGH Injection: instructions for use

Experts recommend using an insulin syringe for injections. To do this, you need to do the following:

  • Dilute the drug with sterile or bacteriostatic water.
  • It is strictly forbidden to shake the vial before use (to mix the liquid and dry components). This will significantly reduce the effectiveness of the drug. It is recommended to gently rotate the vial to mix the main ingredients for an injection.

How to use hgh injection in order to achieve maximum efficiency? It is recommended to choose the abdominal region as an optimal area for injections. The best option is to make an injection into the area between the skin and the muscles. Experts indicate that each new injection should be made in another area (to avoid lipodystrophy – destruction of the fat layer).

Slowly inject the drug into the tissues. Hgh injection should be done only with clean hands.

The duration of the course is several months. The maximum efficiency is observed if you start using this product with minimal dosages. It is also recommended to reduce the amount of the drug used at the end of the course.

The dose of hgh in medicine varies depending on the disease. As for the treatment of growth hormone deficiency in adults, the initial dose is about 0.5-1 IU. As for long-term treatment, the recommended dose is no more than 3-4 IU. The average dose of growth hormone used to treat adults is 2 IU. Hgh is a prescription drug that can be prescribed only by doctors who specialize in endocrinology, pediatric endocrinology or pediatric nephrology.

Hgh injection for athletes: at the first stage, the optimal dose for one injection is 4 IU. The amount can be increased after a month to 4.5-5 IU. You need to slightly reduce the dose of this drug in the presence of any side effects (joint pain, bloating). Do not miss the doses. The minimum interval between injections is 4 hours. It is necessary to avoid foods that contain easily digested carbohydrates.

Hgh works when you are sleeping. Therefore, in this case, the injection should be made in the morning. Thus, it is possible to prolong the process artificially. It is recommended to make injections on an empty stomach.

As for the athletes, hgh injections should be made according to certain rules. The course and dosage depends on the type of physical activity. For example, the dosage for athletes is 8 IU per day, which is not enough for weightlifters. Bodybuilders can take at least 12-16 IU for at least three months. These injections should be done in large dosages for a simple reason: the receptors adapt to the drug very quickly.

Recommendations from specialists: somatotropin for injection can be stored only in the refrigerator at a temperature of +2 + 8° C. Avoid direct sunlight, do not heat and do not freeze the vial. Hgh powder can be stored for no more than 2 years.

HGH Side effects

To be completely honest, there is a need for HGH injections for some population groups. Thus, HGH can be used to treat children and adults who have a significant growth hormone deficiency. However, endocrinologists from around the world strongly recommend avoid using injections without extreme urgency.
One of the main dangers of human growth hormone injections is an uncontrolled effect on IGF-1 (insulin-like growth factor 1) levels. This can lead to serious health problems:

  • Diabetes;
  • Hand or leg edema;
  • Carpal tunnel syndrome and symptoms of arthritis;
  • Headaches and joint pain in the muscles;
  • Abnormal growth of bones and internal organs;
  • High blood pressure;
  • Bloating;
  • Hardening of the arteries.

For these reasons, HGH injections should be done with caution and with the help of a qualified doctor.

How to regulate the levels of HGH
You can increase HGH levels in several ways:

  • Start using drugs based on somatotropin (these drugs are mainly used for therapeutic purposes in case of clinical signs of growth hormone deficiency).
  • Peptide stimulation (creating peak hormone concentrations, increasing the basal concentration of HGH, etc.).
  • Physiological mechanisms that can regulate the production of growth hormone (healthy diet, regular physical activity, healthy sleep habits).

Any physical activity is a good stimulation of growth hormone production. However, some types of physical activity are simply the best for the synthesis of somatotropin: aerobic training, running, skiing, etc. That is, it will be enough to run or walk daily to keep your body in tonus.
Those who want to increase growth hormone levels should choose high-protein foods (these products contain amino acids that stimulate the production of growth hormone). It is better to exclude sugar (a sharp increase in the concentration of glucose suppresses the synthesis of growth hormone). Wholemeal bread, vegetables, fruits, cereals will be perfect.
At least 8 hours of sleep every night will help increase the level of growth hormone. Therefore, you should go to bed early (your sleep should last at least 8 hours).


HGH rarely causes side effects if used in moderate doses. Almost all side effects are reversible. At the same time, it was clearly proven that HGH helps improve physical strength, reduce the level of harmful cholesterol, improve skin properties, strengthen bones and ligaments and rejuvenate the body.
A sufficient level of HGH is important for growth and good health. The question is what to choose: increase the level of the hormone naturally or use synthetic drugs. Note that the human body responds best to the natural stimulation of physiological processes. Any artificial routes (growth hormone injections, peptides, etc.) may have a lot of complications and side effects. Therefore, everything that is done to improve health should be as natural as possible.