Sibutramine is a drug that was originally developed and sold by Knoll Pharmaceuticals under the brand name Meridia. Therefore, this is the most popular brand for this substance. Later Abbott Pharmaceuticals started to manufacture Meridia (Sibutramine). Nonetheless, in 2010, FDA banned Sibutramine making it a schedule IV medication.
Nowadays, you cannot buy Sibutramine legally. Nonetheless, there are still a lot of people who use it for their fat and weight loss goals. That’s because Sibutramine is an awesome appetite suppressant drug.
In fact, Sibutramine was the first drug approved for treating obesity. This was the only use of Sibutramine – to help people lose weight in combination with a proper diet and exercise. That’s because they were able to consume fewer calories than they were burning as their appetite was lower. Needless to mention that it was highly helpful in dealing with weight and body fat loss needs.
Athletes and bodybuilders, obviously, also got interested in the use of this product. Given the fact they were already working out and dieting properly, adding Sibutramine to their cycles greatly helped them.Â
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How Sibutramine Works
Sibutramine is an uptake inhibitor. The compound is working outside the cells for stopping serotonin from reabsorption by the serotonin norepinephrine reuptake receptors. Serotonin works as a neurotransmitter in the body. You may know it as a chemical that is regulating your mood, appetite, and sleep. This is why a lot of antidepressant drugs are using serotonin inhibiting substances. This is why a lot of these drugs are affecting your mood, your appetite, and your sleep.
- So does Sibutramine. It greatly reduces appetite, but it might affect your mood and sleep too. It helps control appetite and this effect lasts fairly long. Moreover, it could affect your mood too. Could enhance or decrease your mood. As a side effect, some people report insomnia (sleep issues).
But it’s highly effective at curbing appetite. In combination with a lower calorie diet and exercise, people do have great success in losing weight. This was proven by studies indicating that people lost 10% of their original body weight. Bodybuilders and athletes could avoid cheat meals and reduce cravings with the help of this compound.
Weight Loss Alternatives
Since its ban, Sibutramine is less popular than other weight loss compounds, such as Clenbuterol and Albuterol. Those are not appetite suppressants (although they do have slight appetite suppression effects), they are rather stimulants.
They are different in the mechanism of action and in results, but they are all helpful in cutting and weight loss cycles. Sibutramine is a schedule IV medication, but Clenbuterol, for example, is banned by FDA too.
How to Use Sibutramine?
 This medication comes as pills only, that’s why you should swallow it. Sibutramine pills have a half-life of 14-16 hours. The peak plasma concentration of Sibutramine reaches about 3-4 hours after the administration.
I strongly recommend using it in the morning, the first thing after waking up. This way you have higher chances of avoiding side effects related to sleep issues (insomnia). You could take it with or without food. I also do not recommend increasing the dosage more often than once in 4 weeks and by no more than 5 mg/day. The starting dosage is 10 mg/day. This means that you could increase to 15 mg/day no sooner than after 4 weeks and may reach 20 mg/day no sooner than after 8 weeks.
I recommend keeping cycles shorter, to about 6-8 weeks. Rarely do some people choose to use it for 12 weeks. While it’s more effective, it’s more likely to cause dependence. Sibutramine has dependence liability.
Bodybuilders (with bigger size and weight) may increase to higher doses. You could start at 15-20 mg/day only if you previously have experience with it.Â
It’s important to remember that if you start using Sibutramine, you should follow a proper diet and workout plan. Using it without proper nutrition and exercising won’t be highly effective. Moreover, after the cycle ends you need to stick to the same plan because your appetite could increase and you could regain back the weight.
Sibutramine Side Effects
As I said, this compound is likely to affect your mood and your sleeping habits (insomnia). Moreover, you should be careful not to develop a habit (dependence) on it.
Some of the most common Sibutramine side effects are insomnia and jitters. But it is likely to cause the common stimulant side effects too such as nausea, headaches, tremors, dry mouth, stomach issues, dizziness, and joint and/or muscle pain among others.
As with all other stimulants, I strongly recommend staying away from them if you have a history of heart conditions. If you suffer from cardiovascular issues, heart issues, and high blood pressure – Sibutramine could make them worse. So it may be wise to stay away from it. If you have a history of such conditions, you need to be extra cautious.
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