Saizen is a synthetic somatotropic hormone, which is identical to natural growth hormone. This somatotropic hormone stimulates bone growth. It activates the biosynthesis of collagen and chondroitin sulfate and increases the excretion of hydroxyproline. In addition, Saizen regulates protein metabolism, and also stimulates muscle cells and thyroid cells. Moreover, this drug reduces cholesterol levels in the blood and promotes faster recovery after injuries. In addition, this drug is able to stimulate the growth of most internal organs, as well as improve certain functions of the central nervous system.
Saizen works in two main directions:
- Anabolic – the drug stimulates muscle growth;
- Anti-catabolic – the drug prevents the destruction of muscle tissue (including age-related atrophy).
In addition, synthetic growth hormone stimulates the synthesis and regulation of protein. As a result, Saizen reduces the formation of fatty deposits, activates muscle growth, improves your bone health, supports immune function and helps rejuvenate skin.
What are the main indications?
Saizen is indicated in the following situations:
- Growth retardation due to insufficiency of growth hormone;
- Turner syndrome;
- Growth retardation in children provoked by kidney failure;
- Growth retardation in children with diagnosed intrauterine growth retardation.
In addition, Saizen is used in case of deficiency of growth hormone in adults.
Saizen for athletes
Saizen is a kind of artificially created growth hormone. Actually, it is similar to the natural analogue. As for sports, this hormone is considered almost indispensable.
The following benefits of Saizen are known:
- Saizen promotes muscle gain;
- It prevents the death of muscle cells;
- This drug destroys fat cells;
- Hgh strengthens the growth of bones and makes your skeletal system stronger;
- Saizen will help boost your immune system and rejuvenate your skin.
Saizen therapy helps create all the necessary conditions for building muscle mass. This hormone burns fat, stimulates the growth of muscles and connective tissues. The hormone has a strong anabolic effect: it improves protein synthesis, which leads to an increase in the size of muscle cells. The second plus of synthetic growth hormone is that it significantly enhances fat burning. It allows your body use more fat to get energy, thus allowing you consume more calories. The third plus of growth hormone is that it strengthens your tissues, ligaments and cartilage. This is the main reason why Saizen therapy is so popular among power athletes, lifters and weightlifters.
What are the main contraindications?
Some Saizen contraindications include:
- Malignant neoplasm;
- Hypersensitivity to somatropin.
With caution: diabetes, intracranial hypertension, hypothyroidism.
Saizen can reduce glucose tolerance. Therefore, this drug should be used with caution in patients with diabetes mellitus.
Pregnancy and lactation
At present, there is insufficient data on the safety of growth hormone during pregnancy. Therefore, it is not recommended to use Saizen during this period. Breastfeeding should be discontinued if it is necessary to use Saizen during this period.
What should you know about Saizen dosage regimen?
It is important to use the drug under the supervision of your doctor. The dosing schedule is determined by the doctor – it depends on the weight of the patient.
Saizen should be used subcutaneously with insulin syringes. A single dose is of 0.5-1.5 mcg (dose equivalents for the natural level of growth hormone). Intramuscular injections are less effective.
Bacteriostatic water or saline solution can be used for injection. Get your ingredients to room temperature before mixing. Do not shake the vial. Do not stir. Gently rotate the vial.
The duration of the course is from 6 weeks to several months.
The usual dose for children with growth retardation provoked by a deficiency of growth hormone production: 0.025-0.035 mg/kg/day.
As for Turner syndrome, the medication is usually prescribed at a dose of 0.045 to 0.05 mg/kg/day.
Growth retardation in children with intrauterine growth retardation: 1 mg/m2 per day or 0.035 mg/kg per day subcutaneously. The therapy is stopped when the patient’s growth reaches values that correspond to those fixed for this category.
Adults: Saizen is used subcutaneously in a dosage of 0.15 to 0.3 mg/day. The recommended final dose usually does not exceed 1 mg per day. In general, small doses are effective. Patients may increase the dosage only under the supervision of a doctor. The dose should be reduced in elderly patients.
Saizen: how to prepare and inject properly
The solution is prepared with bacteriostatic water. The prepared solution for subcutaneous injection should be clear and free of visible particles. The prepared solution for injections must not contain visible particles.
Patients should get detailed instructions on how to properly perform the procedure. You should carefully read the instructions for using Saizen or consult a doctor, nurse or pharmacist.
Prepare the solution on a clean surface. Wash your hands with soap and water.
Saizen injections should be made in different parts of the body. Do not inject if the area is surrounded by redness, swelling and pain. All symptoms should be reported to your doctor.
What should you do if a dose is missed?
Patients should inform the doctor if a dose is missed or an excessive amount is administered. An increased dose will result in a change in the glucose level (patients may experience dizziness). If you take high doses for a certain period of time, this will cause excessive growth of bones (mainly the bones of the hands, feet and jaw).
What are the side effects?
Saizen sometimes causes redness, soreness, swelling of the tissues and itching. In addition, common side effects may include intracranial hypertension, headaches, nausea, vomiting. In addition, peripheral edema, myalgia, paresthesia, tenderness in the joints are observed. In some cases patients may suffer from weakness, fatigue, gynecomastia, scoliosis progression, allergic reactions.
What should you know about Saizen overdose?
Overdose symptoms: There are no reports of acute overdose symptoms. Nevertheless, a dose that exceeds the recommended one can lead to hypoglycemia. Prolonged overdose may result in signs and symptoms characteristic of excess growth hormone – active growth of bone tissue, hypothyroidism, low cortisol levels, etc.
Overdose treatment: drug withdrawal, symptomatic therapy.
Saizen special instructions
Saizen therapy should be started after preliminary examination and under compulsory supervision. Your doctor must have many years of experience in the treatment of patients with growth hormone deficiency.
If you use Saizen subcutaneously over a long period of time, this can lead to damage of the skin. Therefore, it is important to change the injection site.
Fundoscopy should be performed if severe headache, visual impairment, nausea or vomiting occur during the treatment period (to detect swelling of the optic nerve). In this case, treatment with Saizen should be discontinued.
Patients over 60 years of age who are being treated with Saizen should be closely monitored. The experience with Saizen in elderly patients is still insufficient.
Drugs that are incompatible with Saizen are not known. Simultaneous application of GCS is not recommended. The effectiveness of the drug may also be influenced by concomitant therapy with other hormones (for example gonadotropin, anabolic steroids, estrogens and thyroid hormones).