Genotropin is a genetically engineered artificial growth hormone that has a powerful effect on metabolic processes. It stimulates somatic and skeletal growth, as well as reduces fat mass and increases muscle mass. Genotropin therapy helps normalize the density and mineral composition of bones in patients with a deficiency of growth hormone and osteoporosis. The drug also lowers cholesterol and stimulates the synthesis of proteins. It helps increase the size of muscle cells, thymus gland, liver, gonads, thyroid and adrenal glands. Genotropin also increases physical endurance.
Genotropin comes in the form of solution for injections containing somatropin as an active substance. The drug affects the intensity of metabolism in the bone tissue. It is used to normalize the structure of the body by reducing fat and increasing muscle mass. It is also used for stimulation of skeletal and somatic growth and normalization of bone density.
Genotropin indications for use: the drug is prescribed to children with growth retardation due to insufficient growth hormone production. It is used in case of Turner syndrome, as well as chronic renal failure. As for adults, Genotropin therapy is prescribed in case of acquired or congenital growth hormone deficiency (as a substitute therapy).
Effects of HGH: how does it work?
Genotropin is a synthetic analogue of somatotropin (human growth hormone). This drug can stimulate skeletal growth due to increased metabolic processes in bone structures. In addition, it helps increase muscle mass, reduce the level of low-density lipoproteins, as well as activate amino acid metabolism. It should be noted that synthetic somatotropic hormone does not directly affect the body: it only stimulates our organism to produce various substances called growth hormones. As a result, cells, bone structures and muscle fibers start to grow and multiply. Such stimulation of cell growth is often used to heal wounds and repair bone tissue after fractures. Therefore, hgh increases muscle activity and physical endurance.
In medical practice, the drug is used as a part of hormone replacement therapy for children with physical developmental delays and growth retardation. Synthetic analogue of somatotropin is also used to restore the level of somatotropin in adults. In addition, the main indications for this synthetic growth hormone include bone fractures, slow healing wounds, ulcerative digestive disorders, osteoporosis (as part of complex treatment), and disorders of lipid metabolism.
Athletes (especially weightlifters) often use hgh injections to build muscle. Recent studies proved that this drug does not stimulate antibody production, which means that it can be used for a long time (more than six months). In addition, there are several positive points of using hgh:
Hyperplasia of muscle tissue - natural growth of muscle cells. This is the main reason why bodybuilders choose hgh therapy.
Rapid fat burning - the normalization of metabolic processes and cholesterol levels leads to a reduction in fat mass. Such effects can be achieved in parallel to building muscles.
Minimal risks and almost complete absence of dangerous side effects (under certain conditions: with proper use of the drug).
Genotropin pharmacological effects
Genotropin is a recombinant somatotropic hormone that promotes skeletal and somatic growth. This drug stimulates bone metabolism and bone growth. Genotropin can increase muscle mass, thus normalizing the structure of the body.
Genotropin therapy in patients with insufficient production of growth hormone and in patients with osteoporosis helps normalize mineral composition and bone density. In addition, the drug helps lower the levels of cholesterol.
Genotropin helps increase the size of muscle cells (as well as liver, thyroid gland, thymus gland and adrenal glands). In addition, Genotropin blocks the secretion of insulin and delays the excretion of potassium, sodium and phosphorus.
What should you know about Genotropin contraindications?
Genotropin is contraindicated in the following cases:
Hypersensitivity to somatropin and additional components of the drug;
Pregnancy and breastfeeding;
Patients after surgery;
Patients with acute respiratory failure.
Genotropin should be administered with caution in case of intracranial hypertension, diabetes, hypothyroidism.
When taking Genotropin, be sure to remember that this medication can affect the effectiveness of other hormonal medications (in case of simultaneous treatment). Therefore, carefully structure your treatment plan if you are taking anabolic steroids, estrogens, gonadotropin or thyroid hormones.
How to take Genotropin: dosing regimen
Practice shows that the highest rate of drug delivery to the body cells is achieved by subcutaneous injection. Genotropin injections should be used once a day, usually before bedtime. Patients should periodically change the injection site in order to prevent the occurrence of lipoatrophy.
Dosages for patients are calculated individually depending on the severity of hgh deficiency, body weight and effectiveness of therapy. Therefore, self-administration of this hormonal drug (without consulting an endocrinologist) is not recommended.
Insufficient production of growth hormone in children: the dosage is 0.16-0.24 mg per kg of body weight per week. Treatment should be started at the earliest possible age and continued until puberty. Treatment should be stopped when the desired result is achieved.
Insufficient production of growth hormone in adult patients: the initial dosage of Genotropin is 0.15-0.3 mg per day.
Turner syndrome, chronic kidney failure in children accompanied by growth retardation: the recommended dosage is 50 mcg per kg of body weight per day.
Lower doses are used in elderly patients.
Symptoms of overdose
Acute overdose can lead first to hypoglycemia, and then to hyperglycemia. Symptoms of excess growth hormone are noted in case of a prolonged overdose: gigantism, acromegaly, hypothyroidism, low cortisol levels. The therapy should be stopped in case of an overdose.
What are the side effects associated with Genotropin therapy?
Genotropin can cause side effects such as increased intracranial pressure, hyperglycemia, hypothyroidism symptoms, leukemoid reactions, myalgia, arthralgia, fluid retention with peripheral edema, tunnel syndrome. As a rule, all of the above symptoms are dose-dependent. Allergic reactions such as pruritus and skin rash are possible.
Other reactions include: itching, pain, swelling, hyperemia and lipoatrophy at the injection sites.
The active substance of the drug can lead to the following side effects:
Pancreatitis (nausea, vomiting and abdominal pain);
Tiredness and fatigue;
Optic disc swelling (mainly in patients with Turner syndrome);
Hearing impairment and otitis media;
Hip subluxation in children;
Progression of scoliosis.
Genotropin blocks the excretion of sodium, phosphorus and potassium from the body. As a result, it is necessary to change your diet preferences or use multivitamin complexes. At the same time, some patients may suffer from calcium deficiency. It is necessary to include calcium-containing foods or vitamins.
What should I know about Genotropin interaction with other drugs?
Glucocorticoids reduce the stimulating effect of somatropin on growth hormones.
The effectiveness of the drug can be reduced by simultaneous treatment with other hormones (gonadotropin, estrogens, anabolic steroids, thyroid hormones).
What should I know about special instructions?
Patients with diabetes mellitus may need to change the dosage of hypoglycemic drugs. In addition, mild thyroid failure may be diagnosed. Signs of hyperthyroidism may appear in patients using thyroxine.
It is necessary to stop using Genotropin in case of edema of the optic nerve.
What should I know about Genotropin storage conditions?
The drug is stored in a dark place at a temperature of 2-8º C.