Arimidex and Nolvadex are very popular medications both in medical settings and in the bodybuilding world. They are both considered orally active products given to women, nonetheless, they are both used by male bodybuilders running anabolic steroids.
These 2 compounds seem to have a lot of things in common, nonetheless, they are still 2 very different products. If you’re wondering about Arimidex Vs Nolvadex for a medical condition (assuming you’re a woman) then we highly recommend you to talk with your doctor as this way you’re going to get the best answer about which compound to choose specifically for your needs.
Nonetheless, if you plan on using anabolic steroids or already do and you are thinking about Arimidex or Nolvadex, then you would find this post very helpful.
What is Arimidex?
Arimidex is the most popular brand for the active substance Anastrozole which is considered a non steroidal anti estrogen and more specifically – an Aromatase Inhibitor (AI) which is used in medical settings mostly for treating breast cancer in postmenopausal women.
Arimidex is often used as a second line treatment of cancer that has progressed after using Tamoxifen Citrate (Nolvadex).
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What is Nolvadex?
Nolvadex is the most popular brand for the active substance Tamoxifen Citrate which is considered a non steroidal anti estrogen but more specifically – a Selective Estrogen Receptor Modulator (SERM) which is used in medical settings for treating or preventing estrogen receptor positive (ER+) breast cancer in women.
Nolvadex might also be used for treating gynecomastia in men or female infertility in women.
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Arimidex vs Nolvadex Similarities
As you can notice, both Arimidex and Nolvadex are anti estrogens and they are both used in medical settings mainly for the treatment of breast cancer in women. That’s all because both these orally active products are known to deal with estrogenic related issues. That’s why they are so similar.
In bodybuilding, both of these products can be used for treating or preventing gynecomastia symptoms. In addition to that, both of these compounds can be used for Post Cycle Therapy (PCT) plans. Since they were both proven effective at restarting natural testosterone production.
So, as much as we can notice, both these compounds have very similar uses, that’s why they are often compared.
Arimidex vs Nolvadex Differences
Despite the fact that these 2 products seem so similar, they are actually extremely different. They are both orally active anti estrogens.
Nonetheless, Arimidex (Anastrozole) is an Aromatase Inhibitor (AI) and Nolvadex is a Selective Estrogen Receptor Modulator (SERM).
Although both deal with estrogens, they are extremely different in the mechanism of action.
- AIs are known to bind to aromatase enzymes and prevent aromatization into estrogen. Therefore, lowers total estrogen levels in the body.
- But SERMs are selectively binding to some estrogen receptors in the body. It works by blocking the activity of estrogen in different parts of the body (like breast tissues, pituitary gland, etc.), but also boosting the activity of estrogen in other parts (like liver, ovaries, etc.).
This is the reason why Nolvadex can be helpful for inducing pregnancy whilst Arimidex is not. This is the reason why Arimidex can be helpful for gynecomastia as well as other estrogen related issues, whilst Nolvadex only for gynecomastia.
With this being said, males running aromatized steroids find that Arimidex is better to use during the cycle because it helps both with gynecomastia and other issues, compared to Nolvadex which only helps with gynecomastia alone. But on the other hand, Nolvadex is way better for PCT because it boosts testosterone way more effectively than Arimidex and plus to that, is not going to suppress estrogens too much.
In the end, most steroid users find out that Arimidex is better for on cycle estrogen protection whilst Nolvadex is better for PCT plans because of the reasons earlier mentioned.
In Conclusion
Nonetheless, these 2 compounds are sometimes stacked together. Either during the use of anabolic steroids, either during PCT plans.
In fact, this applies to all other Aromatase Inhibitors except for Arimidex (Anastrozole) such as Aromasin (Exemestane). As well as all other Selective Estrogen Receptor Modulators except for Nolvadex (Tamoxifen) such as Clomid (Clomiphene).
In the end, most bodybuilders would require both of these compounds as much as you can understand.
Arimidex for estrogenic protection during the cycle.
Nolvadex for PCT plans to restart production of testosterone.
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